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KMID : 0882420110810050641
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Korean Journal of Medicine
2011 Volume.81 No. 5 p.641 ~ p.646
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Hypothyroidism with Suspected Ovarian Malignancy: A Case Report
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Kim You-Jeong
Kim Seong-Man
Chon Min-Gu
Jhi Joon-Hyung
Kim Dong-Jun
Song Yeo-Jeong
Kim Tae-Ik
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Abstract
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We report a 44-year-old woman with massive ascites, elevated serum carbohydrate antigen 125 (CA 125) concentrations, pericardial effusion, and junctional bradycardia. Ascites caused by hypothyroidism are rare, and the pathogenesis is unclear. The ascitic fluid showed elevated total protein concentrations and a high serum-ascites albumin gradient. The massive ascites and increased serum, ascitic, and pericardial CA 125 concentrations led us to make an incorrect presumptive diagnosis of an ovarian malignancy with metastasis. However, there was no evidence of malignancy except the elevated CA 125 level. Similar to ascites, also junctional escape rhythm with marked bradycardia is a very rare feature of hypothyroidism. Following thyroid hormone replacement, the ascites and serum CA 125 gradually decreased, and the heart rhythm returned to sinus bradycardia. We report this case with a brief review of the literature.
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KEYWORD
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Ascites, Bradycardia, CA-125 Antigen, Hypothyroidism, Pericardial Effusion
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